ProFerment: Probiotic with Prebiotic For Great Digestion

By Dr. Bob McCauley, ND

A proliferation of harmful bacteria in the gut can rob your body of the essential nutrients it needs by consuming those nutrients that your body would normally absorb. Probiotics are the friendly bacteria that help keep the intestines healthy and assist in digestion and nutrient absorption. ProFerment is a unique blend of acidophilus (DE111) and a prebiotic PreforPro. In clinical studies, DE111 has been shown to drive out unwanted bacterial pathogens. ProFerment contains PreforPro which has been shown in more than 20 clinical studies to accelerate the growth by at least 10 fold of many types of probiotic species.


Studies also showed that ProFerment significantly decrease in both Total and LDL cholesterol in the body. All disease derives from our diet and are first born in the digestive tract.


The probiotic benefits of DE-111 Bacillus subtilis for digestive and immune health include:

  • Crowds out bacterial pathogens and maintains healthy gut flora
  • Supports the normal immune reaction of intestinal cells
  • Communicates with intestinal cells to maintain the gut barrier’s function
  • Can persist in the GI tract, increase its numbers and then re-sporulate.

In in vitro tests under physiological conditions, PreforPro has been shown to accelerate the growth of a broad spectrum of probiotic species, including:

  • B. bifidum
  • B. breve
  • B. animalis
  • B. longum
  • L. acidophilus
  • L. paracasei
  • L. casei
  • L. rhamnosus
  • Lc. lactis
  • B. subtilis

Functions in Both Small and Large Intestine

Figures 1 & 2 show the difference in growth rate of beneficial Bacillus subtilis and Lactococcus lactis bacteria after the introduction of undesirable E.coli bacteria.

B. subtilis growth after 5 hours under physiological conditions, competing with E. coli

In-vivo growth of beneficial bacteria, B. longum, when competing with undesirable bacteria, E. coli, in different sections of the gastrointestinal tract of mice that were administered PreforPro in ProFerment.

Lactococcus lactis growth after 5 hours under physiological conditions, competing with E. coli

Human Clinical Study

In a human clinical study, PreforPro was shown to influence the microbial population of the gut, while also producing positive effects on cholesterol and immune response. Participants were administered one 15mg PreforPro capsule daily. When compared to the placebo group, results of the study indicated:

  • PreforPro substantially enhanced the growth of beneficial bacteria, including Bifidobacterium animalis, Lactobacillus delbrueckii and Lactobacillus lactococcus.
  • A significant decrease in LDL cholesterol was observed in the total study population, as well as a trend toward decreased total cholesterol.
  • Participants with excess lipids in the blood showed both clinically and statistically relevant decreases in total cholesterol and LDL cholesterol.
  • A significant decrease in the allergy-inducing interleukin 4 (IL-4) cytokine







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Dr. Bob’s Blog is not intended as medical advice. The writings and statements on this website have not reviewed and/or approved by the FDA. Our products are not meant to diagnose, treat, cure or prevent any disease. Rather they are meant to demonstrate that aging can be slowed and even reversed and that Great Health achieved when the most fundamental nutritional needs of the human body are met. Always consult a medical doctor or other medical professional when you consider it necessary.
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About Bob McCauley

Bob McCauley, ND (Robert F., Jr.) was raised in Lansing, Michigan and attended Michigan State University (BA, 1980 in Journalism). He is a naturopathic doctor, Master Herbalist and a Certified Nutritional Consultant. He has traveled extensively, both domestically and abroad, visiting over 32 countries. He published Confessions of a Body Builder: Rejuvenating the Body with Spirulina, Chlorella, Raw Foods and Ionized Water (2000), Achieving Great Health (2005), The Miraculous Properties of Ionized Water, (2006) which is the only book on the market that exclusively addresses Ionized Water, Twelve (Fiction, 2007) and Honoring the Temple of God (2008). He considers himself a Naturalist, meaning he pursues health in the most natural way possible. He studies and promotes nature as the only way to true health. From 2002-2004 he hosted the radio program Achieving Great Health, which was heard by thousands of people each day. His guests included some of the most well-known and respected names in the natural health world. With the help of his father, Dr. Robert F. McCauley, Sr. (Doctorate in Environmental Engineering, MIT, 1953) they started Spartan Water Company in 1992, which sold vended water machines in supermarkets. Robert Jr. founded Spartan Enterprises, Inc. in 1993. He is a Certified Water Technician with the State of Michigan. He is also a Type II Public Water Supply Specialist and has the certifications of S-5 and D-5. The McCauley family has a long history in the water industry. Bob's father pioneered environmental issues regarding ground water and drinking water quality. He received his Ph.D. from the Massachusetts Institute of Technology (MIT) in 1953 for his thesis on removing radioactive strontium from water. He earned his doctorate in Environmental Engineering in less than 2 years, one of the shortest doctoral studies in the history of MIT. He taught civil, sanitary and environmental engineering at Michigan State University for 18 years before retiring to run Wolverine Engineers & Surveyors of Mason, Michigan, for 17 years. His reputation throughout Michigan as a water quality expert was legendary. Bob worked for his father's company for 12 years learning the water business, which dealt primarily with municipalities, including water quality and sanitary sewer issues. After apprenticing with his father, Bob moved on to the bottled water business. He established greater Michigan's biggest selling bottled water: Michigan Mineral – Premium Natural Water. He was introduced to Ionized Water in 1995 and has done more to promote Ionized Water than anyone else in the industry. Bob often lectures and offers seminars on his Seven Component Natural Health Protocol . Bob is a Certified Nutritional Consultant and a Certified Master Herbalist. He is also a 3rd Degree Black Belt and Certified Instructor of Songahm Taekwondo (American Taekwondo Association).
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